The most effective drugs for lowering blood pressure are the long-acting calcium antagonists of choice, such as nifedipine extended-release or controlled-release tablets. These drugs lower blood pressure very quickly, lower blood pressure by a large margin, lower blood pressure effect is good, the larger the dose, the better the effect of lowering blood pressure. If a very small dose is used in combination with other antihypertensive drugs, it can also achieve a very good effect, and has few side effects and is suitable for long-term use. It is just not suitable for use in patients with heart failure, low sinus node function or heart block. The blood sugar, blood fat, the elderly, the heavier salt eaters, and people who like to drink alcohol are not affected; if there are elderly people who often have back and leg pain, taking some drugs such as ibuprofen and fenbendazole are not affected.