The following symptoms should be alert to the possibility of rheumatic disease: 1, joint swelling, pain or morning stiffness Most rheumatic immune disease manifestations have joint symptoms, can be mild or heavy, can last for a short period of time, can also last for a long time, can be accompanied by local redness and fever, can also be manifested only as pain. They may be wandering or fixed, or they may be episodic. It is important to note that if there is significant swelling of the joint, it is essential to see a doctor. Morning stiffness: When waking up in the morning or after resting, the joint appears stiff and movement is limited, affecting turning over, buttoning clothes, clenching fists, etc. This feeling disappears only after activity. 2, lower back pain and alternating hip pain Many patients with ankylosing spondylitis, undifferentiated spondyloarthropathies, etc. can have these symptoms, mainly manifested as back pain at night, especially in the second half of the night and wake up, accompanied by a sense of morning stiffness, the symptoms can be improved after activity. 3, heel pain or other tendon end pain Many seronegative spondyloarthropathies can show these symptoms. 4, unexplained fever For long-term fever, after antibiotics or anti-tuberculosis treatment is ineffective, and exclude tumor, must consider the possibility of rheumatic immune disease. 5, skin symptoms rash, oral ulcers, external genital ulcers, reticular bruising, skin ulcers, etc. 6, Raynaud’s phenomenon Raynaud’s phenomenon is that the hands or feet turn white when it is cold or mood change, turn red when it gets warm or mood stability, and finally turn to normal color. Many diffuse connective tissue diseases such as mixed connective tissue disease, systemic sclerosis, systemic lupus erythematosus, etc. can appear this phenomenon. 7.Dry mouth and eyes Dry mouth and eyes are not only seen in diabetes, use of certain drugs such as antidepressants and urolithiasis, but more often seen in primary or secondary dry syndrome. 8.Myalgia and muscle weakness Such as dermatomyositis, polymyositis, metabolic myopathy and tumor-induced myopathy can appear this performance. 9.Multi-system or organ damage Most diffuse connective tissue diseases such as systemic lupus erythematosus, systemic vasculitis, systemic sclerosis, etc. can involve multiple organs or systems throughout the body. Other manifestations such as recurrent thrombosis, joint or muscle stiffness, recurrent auricular swelling and pain, recurrent purulent or bloody nasal discharge, recurrent miscarriage, waxy fingers (toes), local or generalized skin sclerosis, generalized pain with insomnia and cold limbs, etc. may be manifestations of some rheumatic immune diseases. In short, the manifestations of rheumatic immune diseases are diverse, and the clinical symptoms listed above are only some common manifestations.