The pain in the sole of the foot when walking is often caused by plantar fasciitis, which can be treated as follows: 1. Avoid walking long distances as much as possible, and wear loose shoes when walking, which can relieve the pain in the lower sole of the foot. 2, Medication is the treatment of oral medication, you can take oral anti-inflammatory and pain-relieving drugs, such as meloxicam, celecoxib, loxoprofen sodium tablets. The topical medication, such as Fotarine ointment or Yunnan Baiyao spray, can also relieve the pain of the plantar plate.