Eye pain with vomiting is a common disease, mainly eye diseases, but also neurological diseases, especially diseases of the brain. First, eye diseases are mainly glaucoma, which can produce pain in one side of the eye, photophobia with nausea and vomiting, and a severe headache, and the patient should go to the ophthalmology department for intraocular pressure measurement. Second, neurological diseases, such as migraine. Patients with migraines often have pain in one side of the eye and head, accompanied by nausea and vomiting, photophobia and phonophobia. The disease often has a family history of inheritance, including parents, grandparents, grandma, grandma, grandpa, and even four generations of children may have a history of headaches. Third, herpes zoster of the trigeminal nerve around the eyes can also produce eye pain with vomiting. Herpes zoster on the same side of the headache for about three days can confirm the diagnosis, and treatment is antiviral, along with the application of neurotrophic drugs and physical therapy. Fourth, cavernous sinus syndrome, due to inflammation of the cavernous sinus of the brain leads to increased pressure in the cavernous sinus, causing obstruction of arterial and venous return of the eye, high swelling of the eye, the eye can not move, accompanied by pain and vomiting symptoms. Fifth, painful ocular muscle paralysis, which is also an inflammatory response to eye disease, ocular muscle paralysis accompanied by eye pain, vomiting, red and congested sclera, etc., can be treated with hormone therapy.