Proton pump inhibitors refer to a class of acid-suppressing drugs that inhibit the secretion of gastric acid, such as the commonly used omeprazole, esomeprazole, pantoprazole, rabeprazole, and lansoprazole are all proton pump inhibitors. These drugs can be enriched in the highly acidic environment of the gastric lining cells and can have the effect of inhibiting gastric acid by inhibiting the hydrogen potassium ATPase, which is often referred to as the proton pump, on the gastric lining cells. This drug inhibits the secretion of basal gastric acid and also inhibits the increase of gastric acid due to irritation. In clinical practice, it mainly acts as an inhibitor of gastric acid and can be used for diseases related to excessive gastric acid, such as gastric ulcer, duodenal ulcer, gastroesophageal reflux disease, upper gastrointestinal bleeding, and stress ulcer. In short, proton pump inhibitors refer to a class of acid-suppressing drugs that inhibit gastric acid by inhibiting the efficacy of the proton pump.