After heart valve replacement, long-term medication should be decided according to individual situation and valve type, not all patients need to take medication for a long time after valve replacement. Generally, patients need to take medication for 3 months after surgery, and then gradually reduce the dosage and stop taking medication under the guidance of the doctor according to the individual situation, while patients with mechanical valves and patients with atrial fibrillation need to take medication for life. Most heart valve replacement patients have some degree of cardiac function damage, and the surgery also has a certain degree of trauma to the heart, therefore, in order to protect and improve cardiac function after the operation, the medication can not be stopped abruptly after the operation. Generally, the medication should be taken for 3 months after the operation, and then the dosage should be gradually reduced and the medication should be gradually stopped under the guidance of the doctor according to the patient’s condition. The duration of medication is also related to the type of valve. There are two types of prosthetic valves, generally, patients with biological valves need to take oral medication for 6 months, and then the medication can be stopped gradually; patients with mechanical valves and patients with atrial fibrillation need to take medication for life. After the replacement of heart valves should pay attention to regular review, so that the doctor timely understanding of the condition of the recovery situation, adjust the treatment program.