Knee effusion may be associated with knee tuberculosis, septic arthritis, knee synovitis, etc. Medications can be given according to the cause. 1. Knee tuberculosis: knee joint effusion caused by knee tuberculosis can be treated with bactericidal drugs such as pyrazinamide, streptomycin and ethambutol. 2. Septic arthritis: Staphylococcus aureus infection can lead to septic arthritis and cause knee joint effusion, which can be treated with cefuroxime sodium, cefoperazone sulbactam, penicillin, erythromycin and other drugs according to the aetiological examination. 3. Knee synovitis: Inflammatory lesions in the synovium of the knee joint can lead to knee joint effusion, which can be treated with drugs such as celecoxib, meloxicam, etoricoxib and glucocorticoids. It is recommended to go to the hospital in time to improve the relevant examination and then carry out the appropriate treatment. All of the above drugs should be applied under the guidance of a physician, and should not be used without authorization.