The possibility of elevated total bilirubin caused by chemotherapy is very high, mostly due to the damage of liver function by chemotherapeutic drugs, which is more dangerous when the value is obviously elevated, which is even more harmful to the organism. Chemotherapeutic drugs can destroy tumor cells in the body, and most of the chemotherapeutic drugs need to be metabolized by the liver and excreted from the body, which is very easy to hurt the liver and cause liver dysfunction, and elevated total bilirubin is one of the manifestations. When the total bilirubin is elevated 2~3 times or even higher, it indicates that the liver cells are severely damaged, and in severe cases, liver failure can be caused, which is life-threatening. At this time, it is necessary to take liver-protecting medications (such as glutathione, silymarin, etc.) intravenously or orally under the guidance of doctors. As mentioned above, the danger of elevated total bilirubin due to chemotherapy depends on its value, the higher the value, the more dangerous it is, then we should actively consult the doctor, standardize liver-protecting treatment and adjust the dosage of chemotherapy drugs according to the doctor’s advice, so as to avoid further damage to the liver.