The normal thickness of the left ventricular wall is 6~12mm, and the thickening of the left ventricular wall by 16mm is not normal, considering the thickening of the ventricular muscle, which is mostly seen in hypertrophic cardiomyopathy and hypertensive heart disease. 1. Hypertrophic cardiomyopathy: It is a myocardial disease characterized by myocardial hypertrophy, mainly manifested by thickening of the left ventricular wall, which usually refers to the thickness of the septum or the left ventricular wall of ≥15mm measured by two-dimensional echocardiography or ≥13mm in those who have a clear family history of it, and it is usually not accompanied by enlargement of the left ventricular cavity. 2. Hypertensive heart disease: long-term hypertension, increased pressure load on the ventricles, increased work done by the ventricular muscle, resulting in compensatory thickening of the ventricular muscle and thickening of the left ventricular wall, which may be accompanied by ventricular enlargement. Left ventricular wall thickening of 16mm is not normal, the patient should be further examined to clarify the cause of the disease.