The most common cause of toothache in the middle of the night is an acute attack of endodontitis. You can orally take fenbendazole and other pain medication to temporarily stop the pain, but can only relieve the moment can not be completely cured. You also need to go to the hospital stomatology department as soon as possible, so that the doctor to find the tooth that causes pain, as soon as possible, symptomatic treatment. Pulpitis because of pulp congestion compression to the nerve leading to pain, and the pulp chamber is a closed space, sleep at night after the change in position on the nerve compression, so there will be obvious symptoms of pain at night. Because of the direct effect on the nerve, the effect of medication may not be too obvious. Doctors use dental drills to open the pulp cavity to decompress and drain the nerve, to relieve the compression of the nerve, the pain will immediately improve. After the pain is relieved, the pulp can be inactivated and cured with a thorough root canal treatment.