If a woman has a manicure without knowing that she is pregnant, it will not have much effect on her pregnancy because the manicure is only a small amount of nail polish applied locally to the nails, and the amount of nail polish absorbed by the body through the nails is very small, so the effect of having a manicure on the embryo is not particularly great. During pregnancy, you need to do regular obstetrical examination, in the 12th week of pregnancy about the NT check fetal nuchal translucency thickness, in the 15th week of pregnancy about the Down’s syndrome or non-invasive GNA, in the 22nd to 24th week of pregnancy about the 3D ultrasound to see the fetal parenchymal organs with or without the presence of malformations, in the 32nd to 34th week of pregnancy two 3D ultrasound to rule out fetal positional anomalies. In addition to the relevant obstetric examinations throughout pregnancy, routine folic acid supplementation is required before the 12th week of pregnancy to prevent the occurrence of fetal neural tube anomalies.