High transpeptidase may be physiologic or pathologic. 1. Physiological increase: serum transketolase mainly comes from the liver, transketolase can help diagnose liver and gallbladder diseases, but there may also be physiological increase, the more common is to drink a lot of alcohol, there will be a temporary high, but after stopping drinking alcohol can be normalized. 2. Pathological elevation: Pathological elevation of transketolase has many reasons, which may be caused by liver diseases, such as infectious hepatitis, cirrhosis, etc. In addition, if there is obstructive jaundice, it will lead to high transketolase inflow into the bloodstream, and some secondary hepatocellular carcinomas, biliary cirrhosis, cholangitis, pancreatic head carcinoma, and extrahepatic cholangiocarcinoma, etc. will also have obvious elevation. Increased transketolase should be taken seriously, and timely consultation should be made for further examination and symptomatic treatment according to the cause of the disease.