Post-radiotherapy mouth ulcers can be treated with medication and other treatments as prescribed by the doctor, and general treatment needs to be strengthened. 1. Drug treatment: for oral ulcers after radiotherapy, usually can follow the doctor’s instructions with local lidocaine gel, benzocaine gel and other drugs to relieve pain, but also can be used 0.05% chlorhexidine gargle, 0.1% isacridine liquid, 1% povidone iodine liquid gargle and cedirizine tablets, ciprofloxacin containing tablets, and other drugs to achieve the purpose of anti-inflammatory. As the local mucous membrane of patients with oral ulcers is damaged, patients can follow the doctor’s instructions to use topical recombinant human epidermal growth factor gel, recombinant bovine basic fibroblast growth factor gel and other drugs to promote healing. In addition to drugs, oral ulcers can also be prescribed oral vitamin B12, vitamin B2 and other vitamins, levamisole, thalidomide and other immune agents. 2. Other treatments: some of the oral ulcers after radiotherapy can be prescribed laser irradiation therapy, which helps to promote mucosal regeneration, ulcer healing. Since mental tension, anxiety and other negative emotions are the triggering factors of oral ulcers, some of the patients with oral ulcers after radiotherapy can follow the doctor’s prescription for psychological treatment if necessary. 3. General treatment: in daily life, mouth ulcers need to master the correct method of brushing teeth, and should also brush their teeth in the morning and evening, rinse their mouths after meals, etc., in order to ensure oral hygiene. Patients should also pay attention to the intake of food rich in vitamins and minerals, and eat less barbecue, pickled food and spicy stimulating food. It is recommended that patients with mouth ulcers after radiotherapy should follow the doctor’s instructions and use medication in order to control the progress of mouth ulcers and improve the quality of life.