Pressing on the eyeball pain may be caused by visual fatigue, blepharitis, inflammation of the eye surface and the eye, glaucoma, and the entry of foreign objects into the eye. 1. Visual fatigue: Long hours of late-night work, continuous close-distance work and study, long-term exposure to electronic products and other bad eye habits may lead to eye fatigue, resulting in pain when pressing on the eyeball. 2. Blepharitis: When the glands of the eyelids are infected by bacteria, redness, swelling and painful pressure may occur locally. 3. Inflammation of the ocular surface and the eye: such as keratitis, conjunctivitis, scleritis, iridocyclitis, etc., all of which may irritate the eye and cause pain when pressed. 4. Glaucoma: Elevated intraocular pressure will cause eye distension and pain, and the pressure inside the eyeball will further increase when pressing, thus aggravating the pain. 5. Foreign body in the eye: foreign body rubbing the surface of the eyeball will stimulate the nerves of the eye and cause pain when pressing. It is recommended that patients go to the hospital for a detailed examination in time to clarify the cause of the disease and follow the doctor’s instructions for treatment.