The following patients need to be killed for H. pylori (HP): gastric ulcer, duodenal ulcer, erosive gastritis, atrophic gastritis, and those with a family history of gastric cancer. in addition, HP killing can be considered for common non-atrophic gastritis that is completely ineffective with regular gastric medication. for general common non-atrophic gastritis, i.e. chronic superficial gastritis, HP killing treatment is not routinely required. Formal protocols: There are two protocols that are the most classical and most commonly used and preferred by physicians. It is important to note that HP killing treatment are shorter than 2 weeks, usually 7-10 days. Antibiotic time can not exceed 2 weeks, otherwise resistant and lead to intestinal bacterial dysbiosis, but easy diarrhea. Option 1, bismuth + two kinds of antibiotics, the course of treatment for 2 weeks 1, bismuth standard dose (Lizudra 2 tablets / each time, three times / daily, before meals) + amoxicillin 0.5 + metronidazole 0.42 times / day after meals × 2 weeks 2, bismuth standard dose + tetracycline 0.5 + metronidazole 0.4 2 times / day × 2 weeks 3, bismuth standard dose + clarithromycin 0.25 + metronidazole 0.4 2 times / day × 2 weeks Option 2: Proton pump inhibitors (PPI: such as omeprazole, rabeprazole, lansoprazole, etc.) + two antibiotics for 1 week 1. PPI standard dose + clarithromycin 0.5 + amoxicillin 1.0 2 times/day×1 week 2. PPI standard dose + amoxicillin 1.0 + metronidazole 0.4 2 times/day×1 week 3. PPI standard dose + clarithromycin 0.25 + metronidazole 0.4 2 times/day×1 week