Patients are often confused by the fact that they are taking antihypertensive medications that are not effective in lowering blood pressure. Some of them are ineffective when taking antihypertensive drugs for the first time, and some of them appear after taking them for a period of time. The key to solving the problem should start from clarifying the cause of the disease. The reasons for the ineffectiveness of antihypertensive drugs can be analyzed from various aspects. 1, the patient did not adhere to the daily blood pressure fluctuations in accordance with the law of taking drugs on time, when the blood pressure is in the physiological peak, the role of drugs has disappeared or not effective; 2, the patient’s bad habits, such as smoking, alcohol, high-fat diet, heavy taste, affecting the effect of antihypertensive drugs; 3, taking short-acting antihypertensive drugs, resulting in blood pressure fluctuations, even side blood pressure when the blood pressure may appear high; 4, secondary hypertension is also one of the causes , as hypertension is caused by other diseases that increase blood pressure, such as hyperthyroidism, adrenal adenoma, etc. Generally antihypertensive drugs are not effective in lowering blood pressure, and blood pressure can be reduced to normal after removing the cause. In addition, hypertension for a long time will be accompanied by target organ damage, such as cerebral thrombosis, heart failure, when the blood pressure fluctuates significantly, there will be patients so-called “antihypertensive drugs ineffective” phenomenon. For the above causes of drug ineffectiveness, once the cause is clearly identified, the cause should be actively treated and the medication should be used reasonably under the guidance of a doctor.