Nodular disease is a non-caseous granulomatous lesion that involves multiple systems of the whole body, and the specific clinical manifestations are mainly related to the organs involved, and the tissues that are easily involved include the lungs, lymph, skin, liver, eyes and the nervous system, etc., and the manifestations that appear include respiratory anomalies, enlarged lymph nodes, skin rashes, impaired liver function, uveitis, and neurological injuries. 1. Lung involvement: mainly manifested as coughing, coughing up sputum, chest pain, and in severe cases, interstitial lung fibrosis may lead to abnormal respiratory conditions or even cause pulmonary heart disease. 2. Lymphatic involvement: lymph nodes are enlarged, not fused, movable, without tenderness, and do not form ulcers or sinus tracts, with cervical, axillary, medial epicondyle of the humerus, and inguinal lymph nodes being most frequently involved. 3. Skin involvement: cause skin damage, nodular erythema of the skin, frostbite-like lupus and subcutaneous nodules. 4. Liver involvement: causes enlargement of the liver and formation of liver nodules, as well as an increase in gammaglutaminase, which may lead to cirrhosis in severe cases. 5. Eye involvement: mainly leads to granulomatous uveitis, but also the sclera, retina and optic nerve may be involved. 6. Nerve damage: facial nerve paralysis, aseptic meningitis, seizures may occur. In addition to the above symptoms, some people may also suffer from decreased kidney function and bone and joint pain. If you find nodular disease, it is recommended that you consult a doctor in time and have standardized treatment under the guidance of a clinician.