Avanafil and Sildenafil usually do not have the so-called which one is better, both are drugs for treating erectile dysfunction in men; patients are advised to choose the drug treatment reasonably under the guidance of doctors. 1. Avanafil: Avanafil is mainly used for the treatment of male erectile dysfunction, overdose of this drug may lead to headache, back pain and other symptoms. This drug should not be shared with nitrates, which may lead to low blood pressure. Patients who are allergic to this drug and women are prohibited. 2. Sildenafil: Sildenafil is mainly composed of sildenafil citrate, which is also used for the treatment of erectile dysfunction, etc. Excessive use of this drug may lead to abnormal ejaculation, genital edema and other adverse reactions. Use this drug under the supervision of a doctor. It is contraindicated in patients who are allergic to Sildenafil Citrate. It is recommended that patients choose the appropriate medication for treatment under the guidance of a doctor after diagnosis in a hospital, and not blindly use the medication on their own.