A patchy short T2 signal shadow in the peripheral band of the prostate with blurred borders is often suggestive of prostate cancer, but it may also be a benign lesion, such as chronic prostatitis, granulomatous lesions, and post-biopsy hemorrhage, which require further differential diagnosis. A short T2 signal in MRI (magnetic resonance imaging) indicates a low-signal black shadow on T2WI. Normally, in T2WI, the anatomical bands of the prostate show different signal intensities due to differences in tissue structure and water content. The migratory bands around the urethra show low signal; the central band belonging to the peripheral glands shows low signal; the peripheral bands belonging to the same peripheral glands show higher signal. 1. The typical performance of prostate cancer on T2WI is the appearance of low-signal nodules in the normal higher-signal peripheral band, at this time, there is a significant difference between the signal of the tumor and that of the surrounding tissues, so it is easy to find early tumors. 2. Chronic prostatitis is enlarged in the early stage and reduced in the late stage, with mixed and uneven signals, often combined with pseudocysts and calcification. 3. Granulomatous lesions and bleeding after biopsy can be seen on T2WI with low signal foci and fuzzy edges. Doctors need to make a comprehensive judgment based on the patient’s medical history, symptoms, physical examination, and other auxiliary examinations, and cannot rely on a single test.