Usually cefixime can not be taken together with amoxicillin, it is recommended to follow the doctor’s instructions for medication. Cefixime and amoxicillin are both beta-lactam antibiotics and cephalosporins, with duplicated antibacterial spectrums and the same target sites, so the two drugs are usually not to be taken together, to avoid duplication of medication. If you combine two drugs, it may also affect the therapeutic effect of the drug itself or promote the occurrence of drug resistance. Some patients are also susceptible to increased adverse reactions, such as diarrhea and rash, when combined. Cefixime is contraindicated if the patient is allergic to cefixime or other cephalosporins. While penicillin allergy and positive penicillin skin test, amoxicillin is contraindicated to prevent allergic reactions. Patients should pay attention to take cefixime or amoxicillin with warm water, not with coffee, carbonated drinks, alcohol and so on. Patients are advised to apply cefixime or amoxicillin according to the doctor’s instructions, and not to use the drug by themselves. If there are uncomfortable symptoms after using the drug, you should stop the drug and seek medical treatment.