There are many reasons for not being able to sleep at night, and the common reasons are as follows: 1. disruption of the normal circadian rhythm, that is, disruption of the biological clock leading to sleeplessness. 2. systemic diseases causing physical discomfort leading to sleeplessness, such as heart failure patients with nighttime panic, chest tightness, and inability to lie down leading to sleeplessness. 3. hormone level disorders causing sleeplessness, such as menopausal women are prone to estrogen secretion disorders, which can also cause sleeplessness. 4. 4, long-term hypertension, hyperlipidemia, hyperglycemia can also lead to sleep disorders. 5, the side effects of certain drugs, such as the abuse of central nervous system stimulants, can also lead to sleeplessness. 6, long-term anxiety, depression can also lead to sleep disorders. But which of the above conditions lead to sleeplessness, it is recommended that it is best to see a neurologist at the hospital to perform relevant tests to clarify the diagnosis.