The depth of progesterone capsules into the vagina is about 9-10cm, and it is recommended that they be placed in the posterior fornix of the vagina to avoid the possibility of the medication being discharged out of the vagina. It is best to rest in bed after inserting the medication in order to minimize the possibility of the medication being discharged from the vagina due to the weight of standing up, so it is better to rest in bed and go to sleep directly. Progesterone capsules inserted into the vagina melt in the presence of secretions and are then absorbed by the mucosal tissues, achieving a certain therapeutic effect in clinical practice. This route of administration should be under the supervision of a doctor, and there are appropriate indications to use progesterone soft capsules for the appropriate treatment. Individuals may be allergic to this drug and the appearance of vulvar itching, localized redness and swelling of the vagina, once allergic to the drug should be discontinued.