Lung cancer bone metastasis chemotherapy carcinoembryonic antigen can not be lowered, generally consider the ineffectiveness of chemotherapeutic regimen or the active growth of tumor, metastasis to other parts of the body and so on. Bone metastasis is the bone damage caused by hematogenous transfer of certain malignant tumors originating outside bone tissue to bone tissue, which is one of the signs that the cancer has entered the advanced stage. At this time, it is necessary to improve relevant auxiliary examinations, such as chest CT, ECT (bone scanning), cranial CT, abdominal ultrasound, etc., to clarify whether the tumor continues to increase in size or appears to metastasize. If the tumor continues to increase in size or metastasis occurs, change of chemotherapy regimen can be considered, and radiation therapy is feasible for bone metastasis. When bone metastasis occurs in lung cancer, bisphosphonate therapy should also be applied under doctor’s guidance, which can reduce or delay the occurrence of bone-related events and improve the quality of life by slowing down bone destruction.