I. Treatment of acute attacks Rest in a quiet and light-proof room. Mild cases can take general analgesics and tranquilizers (such as aspirin, ibuprofen, etc.), and most of them can be alleviated. If the headache is accompanied by nausea and vomiting, methotrexate can be applied. For persistent migraine and severe migraine, Thorazine (1mg/kg) can be administered orally or intramuscularly or ACTH 50 units intravenously (in 500ml glucose water), or prednisone 10mg orally 3 times a day. Patients with prolonged attacks should pay attention to appropriate rehydration and correction of water and electrolyte disorders. Long-term prophylactic medication should be considered for those who have 2 to 3 headache attacks per month. This kind of medication should be taken daily and the effect should be seen at least 2 weeks after taking the medication. If the effect continues to be taken for 6 months, then gradually reduce the dosage to stop. 1. Propranolol is a beta-adrenergic receptor blocking agent. About 50% to 70% of patients effective, 1/3 of patients can reduce the number of attacks by more than half. The general dosage is 10 to 40mg, 3 times a day. The side effects are small, and the gradual increase in dosage can reduce nausea, ataxia and painful spasms of the limbs and other adverse reactions. 2, benzothiazide 5-HT antagonist, also has antihistamine, anticholinergic and anti bradykinin effect. The common dose is 0.5mg once daily, slowly increasing to 3 times daily. With continuous treatment for 4-6 months, 80% of patients have improved headache or stopped having attacks. Side effects are drowsiness and fatigue, can increase appetite, long-term use will be fat. 3.Maximaximil 5 – HT antagonist, mainly to 5-HT2 receptors have antagonistic effect. Need to start taking small doses (0.5 to 1mg/day) and gradually increase to 1 to 2mg within a week, twice a day. It can cause side effects such as nausea, vomiting, dizziness, drowsiness, etc. Long-term use can lead to retroperitoneal tissue and pulmonary-pleural fibrosis. It must be stopped for 1 month after 6 months of continuous administration. Consider trial only in the most recalcitrant patients. 4, calcium channel blockers such as nimodipine (nimodipine) and flunarizine (flunarizine, Cipro), the common dose of nimodipine is 20-40mg, three times a day. Drug side effects are small, can appear dizziness, head swelling, nausea, vomiting, insomnia or skin allergies and other discomfort. 5.Sodium valproate 100～400mg, 3 times a day. 6.Amitriptyline is a tricyclic antidepressant, can block the re-uptake of 5-HT. It is mostly used for antidepressant and treatment of chronic pain, and is effective for migraine with tension headache. The common dose is 75-150mg/day. 7. Colistin can inhibit the vasomotor center and has hypotensive effect. The effect of migraine prevention is weak, but a small amount of application has no side effects. 2~3 times daily.