There is no such thing as the most effective treatment for toothache in late pregnancy. It is recommended to control diet, local cold compresses, and if necessary, hospital outpatient treatment. 1. Diet control: when a toothache occurs in late pregnancy, you can use concentrated salt water to rinse your mouth, which has a certain bactericidal effect and can relieve the pain to a certain extent. If the pain is caused by carious cavities, it is recommended to pay attention to diet and avoid intake of stimulating food, which may aggravate the pain. 2. Local hot compresses: late pregnancy caused by toothache, you can use cold water or towels wrapped in ice local cold compresses, can achieve analgesia, swelling effect. 3. Go to the hospital for treatment: If the pain is more obvious, it is necessary to go to the hospital for examination. If the pain is caused by bacterial infection, it is necessary to give penicillin and other anti-inflammatory drugs to treat the pain, which can reduce the inflammation and relieve the pain. Such drugs, need to be used under the guidance of a doctor. If the toothache is accompanied by localized obvious swelling, the pain can be relieved by surgical incision and drainage if necessary. To summarize, there are many reasons for toothache during pregnancy, so it is recommended to understand the cause of the pain first, and then give treatment for the cause.