Recently, after undergoing “total parathyroidectomy + autologous parathyroid implantation”, Wang was discharged from the Department of Otolaryngology, Head and Neck Surgery. Nine years ago, Lao Wang suffered from uremia and had to rely on artificial kidney – hemodialysis to remove toxins from his body for a long time because there was no suitable kidney source for kidney transplant. However, misfortune came one after another. In the past 2 years, Wang’s height was reduced from 169cm to 162cm, a full 7cm less, and his whole body itched and had bone pain, and when it was intense, his body was like falling apart, and it was difficult to sleep at night. What is even more painful is that the body bones seem to be made of ceramic, and several falls without thinking, actually fractured many fractures, lying in bed for more than half a year. After the nephrologist’s examination, it turned out that Lao Wang’s pain originated from the secondary hyperparathyroidism after uremia dialysis. After several twists and turns, Lao Wang, who was ineffective in medication, came to Guangdong Provincial People’s Hospital for consultation in the Department of Otolaryngology, Head and Neck Surgery. With the close cooperation of the Department of Nephrology and the Department of Anesthesiology, the meticulous surgery was carried out smoothly as scheduled, and after the surgery, the bone pain and itching that had tormented Lao Wang for several years were soon relieved. According to Dr. Chen Liangzi, deputy chief physician of otorhinolaryngology, secondary hyperparathyroidism is one of the common complications of end-stage renal disease, which disrupts calcium and phosphorus metabolism in the body, causing renal bone disease and other organ damage, which can manifest as bone pain, osteoporosis, fracture, skeletal deformity or metastatic calcification of skin, joints and cardiovascular disease, seriously affecting the quality of life and mortality. Most patients with secondary hyperparathyroidism can effectively control disease progression with pharmacological treatment such as adequate dialysis, calcium supplementation and active vitamin D. Some patients with refractory secondary hyperparathyroidism require surgical treatment, of which “total parathyroidectomy + autologous transplantation” is the most effective. At present, only a few large tertiary hospitals in China perform these procedures in endocrine surgery, general surgery and otorhinolaryngology-head and neck surgery. In addition to the difficulties in protecting the recurrent laryngeal nerve and identifying the possible ectopic parathyroid glands, there are also challenges such as delayed awakening due to renal failure affecting the metabolism of anesthetic drugs, hypercalcemia due to hyperparathyroidism, hypocalcemia after removal of parathyroid glands, and possible combination of infection, osteoporosis, anemia and hypertension. Multidisciplinary cooperation is the key to ensure smooth recovery of patients during surgery and the perioperative period. Based on the availability of a large number of head and neck surgeries, fine neck anatomy, and minimally invasive surgical skills, and with the cooperation and support of our nephrology and anesthesiology departments, the Department of Otolaryngology, Head and Neck Surgery of Guangdong Provincial People’s Hospital has surgically cured more than 10 patients with secondary hyperparathyroidism.