Intestinal plasma membrane layer roughness, i.e., intestinal plasma membrane surface roughness, is the description of enhanced CT, and its possible causes are more, which can be due to benign diseases such as ulcerative colitis, Crohn’s disease, etc. and malignant diseases such as intestinal cancer. 1. Benign diseases: common bacterial enteritis, ulcerative colitis, Crohn’s disease, etc., patients may have abdominal pain, diarrhea, urgency and heaviness (discomfort in the lower abdomen, wanting to defecate very much, and feeling of incomplete defecation after defecation), etc., and in addition, due to the long-term consumption of the disease, the patients may have the manifestation of emaciation and fatigue. This kind of disease in the enhanced CT can be manifested as the plasma membrane surface roughness. 2. Malignant diseases: when intestinal cancer, the intestinal wall around the tumor may show segmental thickening, and the imaging examination may show intestinal plasma membrane surface roughness. For those who have intestinal plasma membrane surface roughness, they need to be further examined under doctor’s guidance to determine the cause of the disease and be treated according to doctor’s instruction.