Physical examination has a lot of splenomegaly, which generally refers to an increase in the volume of the spleen, and may be due to physiological causes, but it may also be due to pathological factors, such as viral hepatitis, cirrhosis, leukemia and so on. 1. Physiological reasons: the general size of the spleen is judged by the thickness of the spleen, which is normally 30~40mm, while more than 40mm is generally judged as splenomegaly. If the physical examination of the spleen does not exceed 45mm in thickness, and is not accompanied by other uncomfortable symptoms, and blood tests are within the normal range, it is generally considered to be physiological splenomegaly. 2. Pathological factors: If the result of physical examination shows that the spleen is obviously enlarged and its thickness is more than 45mm, it is considered to be caused by pathological factors, such as viral hepatitis, cirrhosis, leukemia and other diseases that can lead to enlargement of the spleen. In addition, if the spleen is mildly enlarged, but accompanied by fever, anemia and other symptoms, it is also necessary to consider pathological splenomegaly. Patients who find splenomegaly on physical examination should seek medical examination in time, and take appropriate treatment measures after the cause is clarified by professional doctors.