The main Chinese medicine meridians involved in colon cancer are liver and spleen meridians, because colon cancer is a digestive organ and involves the spleen meridian, which is responsible for transportation and transformation. For example, the five herbs soup, which is commonly used in clinical practice, i.e., Amaranthus, Semen, Cyperus, and Severus, has an anti-inflammatory effect and inhibits the growth of colon cancer. In addition to the internal use of tonics, patients can also use acupuncture and moxibustion externally, which also has certain effect. However, the main evidence-based treatment still needs to be adjusted according to the liver and spleen meridians, and through TCM evidence-based treatment and specialized medicine treatment, the patient’s constitution can be adjusted to improve clinical symptoms, such as abdominal pain, diarrhea, abdominal distension and other uncomfortable symptoms, and improve the quality of survival.