Atopic dermatitis (AD) is a relatively common chronic recurrent pruritic skin disease with clinical manifestations varying with age. In infancy (infantile eczema, commonly known as tinea cruris), the typical presentation is erythema, papules, and blisters on the cheeks, forehead, and scalp, accompanied by intense pruritus. In children, the typical lesions are mainly chronic lesions such as papules and plaques with mossy changes, mainly involving the hands, feet, wrists, ankles and N fossae. In adults, the lesions are mainly dry, scaly erythema, papules, plaques, and some larger mossy plaques, mainly on the folds, face, neck, upper extremities, back, dorsum of hands and feet, and toes. About 45% of children with atopic dermatitis develop the disease within the first 6 months of life, 60% develop it within 1 year of age, and more than 85% develop it before 5 years of age. 20% of children with atopic dermatitis before 2 years of age have persistent symptoms, and 17% have intermittent recurrent symptoms before 7 years of age. Nearly half of the children with this stage of eczema experience complete remission by the second year, but at least one-third have recurrent episodes that extend into adulthood. The prognosis of early-onset AD is related to disease severity and the presence of atopic sensitization (certain foods, such as milk and eggs, and airborne allergens, such as dust mites and pollen). Sensitization to food allergens (e.g., milk, eggs) and airborne allergens (e.g., pets, dust mites, and pollen) is a risk factor for exacerbation of atopic dermatitis and is associated with persistent atopic dermatitis and associated allergic rhinitis and asthma in adolescence and adulthood.