Itchy calf skin at night may be caused by physiological factors such as not paying attention to hygiene, or it may be related to scabies, hives and other diseases. 1. Physiological factors: If you don’t do a good job of cleaning before going to bed, resulting in poor local hygiene, or excessive dryness of the calf skin, it may lead to itching of the calf skin at night. 2. Scabies: the cause of the disease is mainly caused with the scabies mite parasitized in the human body. Patients will have localized pimples, blisters and other symptoms, accompanied by intense itching, the rash can be seen all over the body. As scabies mites are more active at night, the itching will be aggravated at night. 3. Urticaria: the etiology may be related to infection, drugs, abnormal immune function and other factors. Patients will have localized itching, the itchy parts will appear light red wind, the wind usually intermittent or daily attacks, the wind often appear at night, will lead to itchy calf skin at night. If itchy calves appear at night, after excluding physiological factors, it is recommended to go to a regular hospital for examination to clarify the cause.