Excluding measurement errors, a high pressure of 221 mmHg and a low pressure of 122 mmHg is dangerous and immediate medical attention is recommended to prevent accidents. High pressure refers to systolic pressure and low pressure refers to diastolic pressure. When the systolic blood pressure is ≥180mmHg and/or diastolic blood pressure is ≥110mmHg, it is already at the level of grade 3 hypertension (severe). Therefore, a high pressure of 221mmHg and a low pressure of 122mmHg belongs to a severe elevation of blood pressure, which can easily cause accidents such as cerebral hemorrhage and myocardial infarction, and should be kept emotionally stable and seek medical attention immediately. In conclusion, high pressure 221mmHg, low pressure 122mmHg is dangerous and should be treated promptly.