If the submandibular lymph nodes do not go away, if there is no discomfort, it is usually not important, it may be chronic hyperplasia; if the progressive enlargement is accompanied by pain, fever and other symptoms, it is more important, because there may be persistent inflammation or lymphatic metastasis and other conditions. The phenomenon of submandibular lymph nodes does not go away, if there is no gradual enlargement and local pain, redness, swelling, ulceration and other symptoms usually does not matter. This is because the lymph node hyperplasia may be caused by repeated inflammation and stimulation in the mouth and throat, and generally will not have adverse effects on health. Submandibular lymph nodes do not go away, if accompanied by obvious pain and fever and other symptoms is more important. Because it is usually related to inflammation, there may be inflammation of the throat or oral cavity, need to actively anti-infection treatment, such as oral amoxicillin capsules. If the enlarged submandibular lymph node is hard, poor mobility, border is not very clear and progressive enlargement is very important. It may be caused by lymph node metastasis of malignant tumors, and effective measures should be taken as soon as possible for treatment. Patients with enlarged submandibular lymph nodes accompanied by pain, fever or progressive enlargement should go to the hospital in time for examination and early diagnosis and reasonable treatment.