Quadruple refers to quadruple therapy, H. pylori recurrence can also be treated with quadruple therapy. The second recurrence of H. pylori may be resistant to drugs, so it is possible that the use of antibiotics may lead to a decrease in the effectiveness of the drug, the need to change the antibiotic treatment, it is best to do a drug sensitivity test first, choose sensitive antibiotics for treatment, the role of the effect is better. H. pylori recurrence means that the original H. pylori infection has not been eradicated. It is not recommended to blindly use drugs to treat the recurrence, it is recommended to go to the hospital first, after the doctor’s consultation, according to the patient’s own condition to choose the appropriate drug treatment, the effect is better, but also need to pay more attention to daily life interventions during the period of treatment, to prevent the disease from recurring.