Patients with uremia may have yellowing of the skin, and in severe cases, even darkening of the skin. Uremic patients are usually complicated by renal anemia, which may cause yellowing of the skin, but some patients may not have yellowing of the skin. Severe uremia patients, due to the accumulation of toxins in the body, it is difficult to discharge the body in a timely manner, there will also be darkening of the skin. In addition to yellowing and darkening of the skin, uremia patients may also experience changes in urine output such as oliguria or even anuria, swelling of the limbs, and digestive symptoms such as loss of appetite, nausea, and vomiting. It is recommended that patients with UTI should standardize their diagnosis and treatment under the guidance of professional doctors in order to improve their quality of life as much as possible.