Erythromycin ointment applied to the wound instead of more pain may be related to the pain of the wound itself or an adverse reaction to the drug. Erythromycin ointment is a topical macrolide antibiotic with anti-microbial properties, and the indications for its use include suppurative dermatoses (e.g., impetigo), acne vulgaris, small burns, and infections of ulcerated surfaces. Some patients experience adverse reactions such as irritation and allergic reactions after use. Therefore, when a wound appears to be more painful after applying erythromycin ointment, the first thing to consider is that the drug stimulates the wound with an adverse reaction of pain and irritation. Of course, it is also possible that the wound itself is caused by the presence of pain. Note that the drug needs to be contraindicated in people who are allergic to the product. Specific use of the drug should be carried out under the guidance of a specialist.