Blisters are medically referred to as blisters. Blisters on the soles of the feet walking pain according to the cause of the symptomatic treatment, generally can be relieved through the blisters, local disinfection, medication, common causes are long-term friction, blisters tinea pedis and so on. 1. Long-term friction: long-term friction stimulates the formation of blisters, small blisters can be sterilized with iodine, alcohol, and let it absorb on its own. Larger blisters can be sterilized locally and then the blister fluid in the blisters can be drawn out with sterile injection, taking care to preserve the blister walls to prevent infection, and finally wiped with iodine and other disinfectant solutions. 2. Herpetic tinea pedis: Herpetic tinea pedis caused by blisters, can be used locally antifungal ointment, such as ketoconazole cream, clotrimazole cream, etc., the symptoms of serious cases can be combined with oral antifungal drugs, such as itraconazole, terbinafine. All of the above drugs have adverse reactions, it is recommended to use under the guidance of a doctor. Blisters on the soles of the feet, walking pain is recommended that patients go to the hospital in a timely manner to improve the examination, to clarify the cause of the disease to give targeted treatment.