The sequelae of injecting ozone into the knee are mainly the infection of the puncture needle tract caused by the puncture injection of ozone into the knee joint, which can lead to an infection of the knee joint. At the same time the short-term severe pain caused by repeated injection treatment may also cause some irritation to the organism. 1. Needle tract infection: In the process of knee puncture, if the needle and other related instruments are not sterilized properly or the operator does not do aseptic operation, it will lead to some external bacteria or fungi entering the puncture hole and causing infection. At the same time, if the puncture site itself has symptoms of infection, the needle tract infection may aggravate the original symptoms. 2. Pain: Ozone can cause transient severe pain when it contacts the site of action or when it is administered into the joint cavity. For patients who require multiple injections, repeated pain may irritate the peripheral nerves and cause discomfort. In the process of ozone injection operation, careful and conscientious operation, meticulous aseptic operation, mastering the strict indications, you can effectively avoid the related sequelae.