Shuji and Mecobalamin can generally be taken at the same time, and will not occur mutual adverse drug effects. 1. Shujinhuaxin Tablet has the effect of relaxing tendons and activating collaterals, activating blood circulation and dispersing blood stasis, and can be used for the treatment of tendon and bone pain, limb constriction, lumbar and back pain, bruises and other diseases. Pregnant women should not take this product. The adverse reactions and contraindications of this product are not clear. 2. Methylcobalamin: its oral use of capsules, tablets, dispersible tablets, etc., can be used for peripheral neuropathy and vitamin B12 deficiency caused by megaloblastic anemia treatment. Adverse reactions such as loss of appetite, nausea and vomiting, diarrhea, etc. are occasionally observed with this product, and the drug should also be discontinued if rash occurs, and is contraindicated in patients with a history of allergy to methylcobalamin or any of the excipients in the prescription. The above drugs are different types of drugs, and the therapeutic effect is different, but both are prescription drugs, so the specific use should be under the guidance of a physician to follow the doctor’s instructions, not blindly take.