The treatment of Helicobacter pylori infection currently applies quadruple drug therapy, including a proton pump inhibitor, two antibiotics and a bismuth agent. 1. Proton pump inhibitor: it can inhibit the secretion of gastric acid and create a suitable environment for antibiotics to kill bacteria. Commonly used ones include Esomeprazole, Omeprazole, Pantoprazole, and so on. 2. Antibiotics: can kill Helicobacter pylori. Two different antibiotics are chosen based on whether the patient is allergic to penicillin and whether there is macrolide antibiotic resistance. Commonly used are clarithromycin, amoxicillin, metronidazole, levofloxacin and so on. 3. Bismuth: It has the effect of protecting the gastric mucosa. Commonly used drugs include bismuth pectin, bismuth subcarbonate, magnesium aluminum carbonate, bismuth potassium citrate. In addition, in the Helicobacter pylori eradication treatment period, to avoid cross-infection, pay attention to dietary regulation are very important, the medication period and the completion of medication, try to implement a separate meal system, to avoid cross-infection between family members, before meals and after meals must wash their hands, these are to avoid Helicobacter pylori eradication during the period of repeated infections of the effective means of smoking patients are recommended to quit smoking. Patients with H. pylori infection should go to the hospital for regular treatment under the guidance of a medical professional.