Hypomotor neuron paresis, also known as peripheral paresis. Symmetrical lower motor neuron paresis of the extremities is caused by motor neuron disease and manifests as symmetrical lower motor neuron paresis of the extremities. The clinical presentation is characterized by the coexistence of upper and lower motor neuron paresis of the limbs without involvement of the sensory system, vegetative nerves, or cerebellar function. The etiology and pathogenesis are unclear. 5% to 10% of patients have a family history of the disease, which is called familial motor neuron disease. In recent years, genetic abnormalities of peroxisomal enzymes have been identified in this group of patients with a family history of motor neuron disease and are thought to be the possible cause of this group of diseases. The theory of autoimmune mechanisms has received much attention since the application of active immunization of animals with anterior spinal cord cells to produce experimental models of motor neuron disease, the increased detection of anti-GM1 antibodies and anti-calcium channel antibodies in the serum and cerebrospinal fluid of patients, and the certain efficacy of immunosuppressive therapy. Any lesion damage to cortical motor projection areas and upper motor neuron pathways can cause upper motor neuron paresis. Common causes include craniocerebral trauma, tumors, inflammation, cerebrovascular disease, degeneration, poisoning, and certain diseases of internal medicine, such as diabetes, hematoporphyria, macrocytic anemia, and vitamin B12 deficiency. Paralysis: Paralysis (paralysis) is the reduction or loss of random motor function and is a common symptom of the nervous system. Paralysis is caused by lesions of upper and lower motor neurons, the pyramidal bundle and peripheral nerves. Any lesion that damages the cortical motor projection area and upper motor neuron pathways can cause upper motor neuron paresis. Common causes include cranial trauma, tumors, inflammation, cerebrovascular disease, degeneration, poisoning, and certain diseases of internal medicine, such as diabetes mellitus, hematoporphyria, macrocytic anemia, and vitamin B12 deficiency. Guillain-Barré syndrome: also known as acute inflammatory demyelinating polyradiculoneuropathy, is an autoimmune disease caused by respiratory viral infection or gastrointestinal infection, after vaccination, and other causes, and its main pathological change is extensive inflammatory demyelination of the peripheral nervous system. The main clinical manifestation is symmetrical flaccid paralysis of the extremities.