Hypomotor neuron paresis, also known as peripheral paresis. It is the result of damage to the motor fibers of the anterior horn cells of the spinal cord (or the motor nucleus cells of the brain nerves), the anterior roots of the spinal cord, the peripheral spinal nerves and the peripheral nerves of the brain. Symmetrical lower motor neuron paresis of the extremities is caused by motor neuron disease, which manifests as symmetrical lower motor neuron paresis of the extremities. Motor neuron disease (MND) is a group of neurodegenerative diseases of unknown origin that selectively damage the anterior horn of the spinal cord and the motor nuclei of the brainstem in a slowly progressive manner. The clinical manifestations are characterized by the coexistence of upper and lower motor neuron paralysis of the limbs without involvement of the sensory system, vegetative nerves, or cerebellar function. The common causes of lower motor neuron paresis are: peripheral nerve injuries, such as lacerations, contusions, compressions, trauma to the brachial plexus, electric shock injuries, radiation injuries, burns, etc.; toxic injuries, including drugs, organic, inorganic, and bacterial toxins; peripheral neuritis, including infectious, post-infectious, and allergic lesions, connective tissue disease, and nodular peripheral neuropathy, etc.; peripheral neuropathy in metabolic diseases; peripheral neuropathy in malignant diseases; peripheral nerve tumors, primary genetically related peripheral neuropathy, etc. 1, genetic abnormalities (20%) have a family history called familial motor neuron disease, in recent years, in this group of patients with a family history of motor neuron disease found genetic abnormalities of peroxidase, and that may be the cause of the pathogenesis of this group of diseases, with the application of anterior spinal cord cells actively immune animals to produce experimental motor neuron disease model, patients in the serum and cerebrospinal fluid anti-GM1 antibodies, the The theory of autoimmune mechanism has received much attention since the application of the experimental motor neuron disease model using anterior spinal cord cells, the increased detection rate of anti-GM1 antibodies in serum and cerebrospinal fluid, and the certain efficacy of immunosuppressive therapy. 2, abnormal immune function (40%) Immune function refers to the body’s resistance to disease, the body’s immune function is completed under the interaction of lymphocytes, monocytes and other relevant cells and their products; immune function is the role of the immune system according to immune recognition. Abnormal immunity can lead to the disease.