Patients with foot pain in the middle of the night, the following reasons are common: First, cold feet: the surrounding environment temperature is too low, in the process of sleeping without paying attention to foot warmth, easy to produce foot cold, the feet will appear obvious blood circulation disorders, muscle tension, the patient will be manifested in the clinical symptoms of foot pain. Through hot compresses, massage therapy, can make the clinical symptoms be relieved. Second, disease factors: patients with long-term diabetes, and poor blood sugar control, can cause peripheral neuropathy and peripheral vascular blood disorders, there will be midnight foot pain clinical symptoms, and not easy to relieve, persistence will affect normal sleep, symptoms will recur, blood glucose presents obvious instability. Sore feet in the middle of the night must be highly valued, early diagnosis, early treatment, can make the clinical symptoms get rapid relief. If the treatment is delayed, the symptoms will persist.