Chronic atrophic gastritis with celiac disease in the second half of the night, bitter and dry mouth is considered to be caused by the disease itself, may also be bile reflux gastritis, cholecystitis and other diseases caused by the need for targeted treatment under the guidance of the doctor, the main drug treatment is omeprazole, cimetidine, domperidone, etc. as well as surgical treatment. Chronic atrophic gastritis with erosion patients may have acid reflux, belching symptoms, when the acid reflux to the oral cavity can appear bitter mouth; can follow the doctor’s instructions to use omeprazole, cimetidine and other acid inhibiting drugs, Rebapatide, magnesium aluminum carbonate and other gastric mucosal protection agent treatment. In addition, bile reflux gastritis, bile reflux to the stomach, and then from the esophagus into the oral cavity can be caused by a bitter mouth, dry mouth hiccups, can be prescribed the use of omeprazole and other inhibitors of gastric acid drugs, bismuth potassium citrate and other gastric mucosal protectants, as well as ursodeoxycholic acid and other choleretic drugs. Cholecystitis can also appear at night bitter mouth dry hiccups symptoms, acute attacks can be used pethidine pain, ornidazole antibiotic anti-inflammatory, to correct the water electrolyte disorders, accompanied by gallbladder perforation, peritonitis, the need to consider surgical treatment. Patients with chronic atrophic gastritis who have bitter, dry mouth and hiccups in the middle of the night are advised to go to the hospital, ask the doctor to clarify the cause of the disease, and follow the doctor’s instructions to take medication.