Once the diagnosis of rheumatic diseases is clear, the corresponding treatment should be started early. Since most rheumatic diseases cause systemic multi-system and multi-organ involvement, the first is to take individualized treatment principles mainly for the related symptoms, such as the application of non-steroidal anti-inflammatory drugs to treat various types of joint swelling and pain, but not to control the progression of the primary disease. Secondly, a combination of anti-rheumatic drugs is also needed to slow down the progression of the disease. Methotrexate, cyclophosphamide, azathioprine, tacrolimus, or cyclosporine A are usually used. Secondly, glucocorticoids can also be used to treat the disease. Hormones are powerful anti-inflammatory and anti-immune agents, so they are the first line of treatment for many connective tissue diseases in rheumatic diseases. Once again, intravenous immunoglobulin infusion as well as plasma exchange and biological agents can be used for treatment if necessary.