Mild hepatosplenomegaly with thickened gallbladder wall may suggest the presence of hepatitis, chronic cholecystitis or cirrhosis. 1. There are many reasons for the formation of mild hepatosplenomegaly, the most common being the presence of chronic hepatitis, so it is necessary to carry out tests for hepatitis B and C viruses, and if there is a viral infection, it is necessary to carry out antiviral treatment in a timely manner in order to prevent the condition from continuing to progress. This situation needs to be carried out under the guidance of specialized doctors. 2. Generally speaking, the thickening of gallbladder wall is often related to the occurrence of chronic cholecystitis, which requires timely treatment to avoid further progression of the disease, and cholecystectomy is recommended, which needs to be done by specialized doctors. 3. It is worth mentioning that if the liver disease has progressed to the stage of cirrhosis, enlargement of the liver and spleen may occur, due to portal hypertension and hepatic decompensation, accompanied by edema of the gallbladder wall. If the above situation occurs, please consult a doctor for reasonable and standardized diagnosis and treatment in time.