Clinical reports of non-calcified plaques in the proximal segment of the left anterior descending branch represent atherosclerosis of the coronary arteries here, which belongs to the category of coronary atherosclerotic heart disease, and coronary atherosclerotic heart disease if the lumen stenosis is >50%. The coronary arteries can be divided into left and right coronary arteries, and the left anterior descending branch is a branch of the left coronary artery. Noncalcified plaque in the proximal segment of the left anterior descending artery represents atherosclerosis in this coronary artery. Noncalcified plaques are usually plaques in which a blockage has formed in the vessel, but the plaque has not been in place long enough for the plaque to form and has a relatively low calcium content. Since non-calcified plaques are not firmly bonded to the vessel wall, be wary of their tendency to dislodge and form blood clots. Once it occurs, we should take statin lipid-lowering drugs to stabilize the plaque and aspirin enteric-coated tablets for antiplatelet aggregation, which are both beneficial to the treatment of non-calcified plaques. Risk factors for the formation of non-calcified plaques in the proximal segment of the left anterior descending branch include hyperlipidemia, hypertension, diabetes mellitus and other underlying diseases, as well as smoking, alcohol consumption, lack of activity, obesity, etc. In addition to standardized treatment as prescribed by the doctor, the patient should actively control the relevant risk factors, low-salt and low-fat diets, increased physical activity, smoking cessation, alcohol cessation and active weight control, and regular checkups.