There are five major classes of first-line antihypertensive drugs in clinical use: 1) diuretics, represented by hydrochlorothiazide; 2) beta-receptor antagonists, represented by metoprolol and bisoprolol; 3) calcium channel blockers, represented by amlodipine, lacidipine, felodipine and nifedipine; 4) angiotensin-converting enzyme inhibitors, represented by captopril, enalapril, benazepril and fosinopril; 5) angiotensin II receptor antagonists, represented by irbesartan, cloxartan, valsartan and timetan, 5, angiotensin II receptor antagonists, the representative drugs are Irbesartan, Coxsartan, Valsartan, Temisartan. These five major first-line antihypertensive drugs are not superior or inferior. When choosing antihypertensive drugs for clinical antihypertensive treatment, they should be chosen reasonably according to the patient’s specific situation, and if necessary, combined with different mechanisms of antihypertensive drugs for combined antihypertensive treatment, antihypertensive treatment should be individualized, and blood pressure should be controlled in the target range for a long time.