The skull is a very important bone tissue in the human body, which plays a key role in protecting the brain, and it is it that builds a defense wall for the brain, so that all the life activities in the skull can function normally. However, the existence of many accidental factors in life may lead to cranial bone defects, once it really happens, we must pay attention to actively treat and repair in order to reduce the damage. In the clinic, there are such patients, they always hold a fluke mentality at the beginning, thinking that they do not have any obvious discomfort, and slowly the defective part may grow back on its own, but the result is unsatisfactory, and the prolonged cranial defect has brought more pain to themselves. Therefore, we would like to remind you that it is very unlikely that the skull defect will heal by itself, and if the diameter of the defect is more than 3cm, then it is even more important to have the skull repair surgery in time. Of course, cranial bone repair surgery must also pay attention to the choice of repair material, the material did not choose the right postoperative effect is not good. Currently, titanium mesh material is widely used in many hospitals for cranial repair surgery. However, through clinical verification, titanium mesh material has many problems, such as postoperative infections, wear and tear of the scalp, affecting postoperative CT MRI examination, and even the risk of material exposure, and so on. What should I do if I have a titanium skull exposure that doesn’t heal? Titanium mesh material exposure should be vigilant, timely to the professional hospital to let the experts for comprehensive evaluation, and remove the material and then re-repair is critical, and to choose a better repair material to replace.