Although migraine is an incurable primary headache, it can cause cerebral white matter lesions, cognitive decline, posterior circulation asymptomatic cerebral infarction and other lesions, which need to be actively treated. Migraine can be characterized by frequent attacks of one or both sides of the throbbing headache, the patient may be accompanied by nausea, vomiting, photophobia, phonophobia, etc., and generally have family heredity, in addition to certain foods, medications, the environment, and overexertion, etc. may cause migraine. In addition, certain foods, drugs, environment and overwork may also cause migraine. If the migraine is severe and has frequent attacks, or even multiple attacks in a short period of time, it will seriously affect the patient’s work and life. However, with reasonable treatment, most migraine patients have a good prognosis. Migraine symptoms can be gradually relieved with age, and some patients can stop having migraine attacks at the age of 60 to 70. As migraine can also cause cerebral white matter lesions, cognitive decline, posterior circulation asymptomatic cerebral infarction and other lesions. Therefore, active treatment is needed to relieve symptoms and improve prognosis. Drug therapy, psychotherapy, biofeedback, cognitive therapy, neurostimulation therapy and other modalities are usually applied. It is recommended that migraine patients seek timely medical treatment, rational treatment, and strictly follow the doctor’s prescription of medication, in order to alleviate the condition and improve the prognosis.